First outbreak of KPC-3-producing Klebsiella pneumoniae (ST258) clinical isolates in a Mexican Medical Center.
نویسندگان
چکیده
Patricia Rodríguez-Zulueta, Jesús Silva-Sánchez, Humberto Barrios, Javier Reyes-Mar, Francisco Vélez-Pérez, Sara Arroyo-Escalante, Luis Ochoa-Carrera, Gabriela Delgado-Sapien, María del Rosario Morales-Espinoza, Elsa Tamayo-Legorreta, Rigoberto Hernández-Castro, Ulises Garza-Ramos Subdirección Epidemiología Hospitalaria e Infectología y Laboratorio Clínico, Hospital General Manuel Gea González, Ciudad de México, México; Instituto Nacional de Salud Pública (INSP), Centro de Investigaciones Sobre Enfermedades Infecciosas, Departamento de Diagnostico Epidemiológico, Cuernavaca, Morelos, México; Departamento de Ecologia de Agentes Patógenos, Hospital General Manuel Gea González, Ciudad de México, México; Departamento de Microbiología y Parasitología Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
منابع مشابه
Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals.
We report the first outbreak caused by colistin-resistant Klebsiella pneumoniae producing KPC-3 carbapenamase in two Italian hospitals. This spread occurred in 1 month, and was caused by eight colistin-resistant and carbapenem-resistant Klebsiella pneumoniae isolates from eight patients. A further three isolates were obtained from the intestinal tract and pharyngeal colonization. All isolates w...
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Increased incidence of infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) was noted among patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) at a single hospital. An epidemiologic investigation identified KPC-Kp and non-KPC-producing, extended-spectrum β-lactamase (ESBL)-producing Kp in cultures from 2 endoscopes. Genotypi...
متن کاملMulticlonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain.
OBJECTIVES To analyse the ongoing epidemiology of KPC-producing Enterobacteriaceae after a non-ST258 KPC-3-producing Klebsiella pneumoniae outbreak in a university hospital in Madrid, Spain. METHODS Enterobacterial isolates (one per patient based on bacterial identification and typing patterns) with carbapenem MICs higher than the EUCAST epidemiological cut-off values, a positive modified Hod...
متن کاملA Long-Term Low-Frequency Hospital Outbreak of KPC-Producing Klebsiella pneumoniae Involving Intergenus Plasmid Diffusion and a Persisting Environmental Reservoir
BACKGROUND To study the molecular characteristics of a long-term, low frequency outbreak of bla KPC-2 in a low prevalence setting involving the hospital environment. METHODOLOGY/PRINCIPAL FINDINGS KPC-producing bacteria were screened by selective chromogenic agar and Real-Time PCR. The presence of antibiotic resistance genes was ascribed by PCRs and subsequent sequencing, and the KPC-producin...
متن کاملMultiplex real-time PCR for detection of an epidemic KPC-producing Klebsiella pneumoniae ST258 clone.
We describe a multiplex real-time PCR assay capable of identifying both the epidemic Klebsiella pneumoniae ST258 clone and bla(KPC) carbapenemase genes in a single reaction. The assay displayed excellent sensitivity (100%) and specificity (100%) for identification of ST258 clone and bla(KPC) in a collection of 75 K. pneumoniae isolates comprising 41 sequence types. Our results suggest that this...
متن کاملKlebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae at a Single Institution: Insights into Endemicity from Whole-Genome Sequencing
The global emergence of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) multilocus sequence type ST258 is widely recognized. Less is known about the molecular and epidemiological details of non-ST258 K. pneumoniae in the setting of an outbreak mediated by an endemic plasmid. We describe the interplay of blaKPC plasmids and K. pneumoniae strains and their relationship to the...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 8 شماره
صفحات -
تاریخ انتشار 2013